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Scientific investigations also examine GHK-Cu in relation to intracellular signaling pathways involving gene expression , transforming growth factor-beta (TGF-) signaling, oxidative stress biomarkers, mitochondrial biology, transcriptional regulation, protein homeostasis, and peptide-mediated molecular communication

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Rivero et al., 2012) are not consistent with this interpretation because they have a G protein-signaling efficacy comparable to morphine but phosphorylate Ser375 (and translocate arrestin) as efficiently as the most efficacious agonists (e.g., DAMGO)

At these higher concentrations, vitamin C functions as a meaningful antioxidant and plays a supporting role in collagen synthesis, immune cell function, and the absorption of non-haem iron